Nine years ago, the Indomitable Lions were beaten by Egypt, who face Burkina Faso in this year's other semi-final, in the showpiece and will be hoping to go one better after a 15-year wait for the African title.
The five-time winners, who will host the 2019 AFCON, face Ghana in the last four.
DATE, UK START TIME AND VENUE
The first Afcon semi-final between Cameroon and Ghana takes place at the Stade de Franceville in Franceville on Thursday February 2. Kick-off is scheduled for 7pm UK time.